Inhalation toxicity of benzalkonium chloride and triethylene glycol mixture in rats
نویسندگان
چکیده
منابع مشابه
Pulmonary irritation after inhalation exposure to benzalkonium chloride in rats.
BACKGROUND Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) with a C8 to C18 chain length of alkyl groups. Since BAC exerts toxic effects on microorganisms, it has been used as an effective germicide and preservative, mostly in cosmetic industry and medicine. However, the toxic potential of BAC may be hazardous to humans, due to the common use of preparations containing BAC a...
متن کاملToxic effect in the lungs of rats after inhalation exposure to benzalkonium chloride.
BACKGROUND Benzalkonium chloride (BAC) is a quaternary ammonium compound (QAC) toxic to microorganisms. Inhalation is one of the major possible routes of human exposure to BAC. MATERIALS AND METHODS Experiments were performed on female Wistar rats. The rats were exposed to aerosol of BAC water solution at the target concentration of 0 (control group) and 35 mg/m(3) for 5 days (6 h/day) and, a...
متن کاملCatecholamine levels in the brain of rats exposed by inhalation to benzalkonium chloride.
OBJECTIVES The aim of the study was to obtain quantitative data on the effect of inhalation exposure to benzalkonium chloride (BAC) on the concentration of catecholamines and their metabolites in selected brain structures. Additionally, concentration of corticosterone (CORT) in plasma was estimated. MATERIAL AND METHODS Wistar rats were subjected to a single (6-hour) or repeated (3 days, 6 h/...
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The objective of this study was to evaluate the effects of Lriethylc}ne glyco] (TEG) and triethylene glycol monomethacrylate (TEG)vlA) solutions as dentin primers on dentin bonding. To this end, wall-Lo-wall polyTnerization contraction gap vL,idth of a resin cornposite ill a cylindrical dentin eavity and shear bond strength to a flat dentin surface were measured. Dentin was pretreated with an e...
متن کاملInhalation toxicity of vinyl chloride and Vinylidene chloride*
Exposure of mice to 1000 ppm of vinyl chloride (VC), 6 hr/day, 5 days/week, caused some acute deaths with toxic hepatitis and marked tubular necrosis of the renal cortex. Starting the sixth month, mice exposed to 1000, 250, or 50 ppm of VC became lethargic, lost weight quickly, and died. Only a few mice exposed to 50 ppm survived for 12 months. Pulmonary macrophage count was elevated in some mi...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2019
ISSN: 0041-008X
DOI: 10.1016/j.taap.2019.114609